dihydrofolate reductase inhibitor


dihydrofolate reductase inhibitor
any of various drugs that interfere with the conversion of folic acid to its active form in the body. They include pyrimethamine, trimethoprim, and methotrexate. When such drugs are necessary, folate deficiency is treated with folinic acid rather than folic acid.

The new mediacal dictionary. 2014.

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  • Dihydrofolate reductase inhibitor — A dihydrofolate reductase inhibitor is a molecule that inhibits the function of dihydrofolate reductase, and is a type of antifolate. Since folate is needed by rapidly dividing cells to make thymine, this effect may be used to therapeutic… …   Wikipedia

  • dihydrofolate reductase inhibitor — any of various drugs that interfere with the conversion of folic acid to its active form in the body. They include pyrimethamine, trimethoprim, triamterene, and methotrexate. When such drugs are necessary, folate deficiency is treated with… …   Medical dictionary

  • Ингибитор Дигидрофолат Редуктазы (Dihydrofolate Reductase Inhibitor) — лекарственное вещество, влияющее на превращение фолиевой кислоты в ее активную форму в организме человека. К этим веществам относятся: пириметамин, триметоприм, триамтерен и метотрексат. Когда больному назначаются эти лекарства, то для устранения …   Медицинские термины

  • Dihydrofolate reductase — Ribbon diagram of human dihydrofolate reductase in complex with folate (blue). From PDB 1DRF …   Wikipedia

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  • Ribonucleotide reductase — protein Name = ribonucleotide reductase M1 polypeptide caption = width = HGNCid = 10451 Symbol = RRM1 AltSymbols = EntrezGene = 6240 OMIM = 180410 RefSeq = NM 001033 UniProt = P23921 PDB = ECnumber = 1.17.4.1 Chromosome = 11 Arm = p Band = 15.5… …   Wikipedia

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  • COX-2 inhibitor — COX 2 selective inhibitor is a form of non steroidal anti inflammatory drug (NSAID) that directly targets COX 2, an enzyme responsible for inflammation and pain. Targeting selectivity for COX 2 reduces the risk of peptic ulceration, and is the… …   Wikipedia


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